氮酮促进吡罗昔康软膏体外释放的实验研究

In vitro experimental study on the release of piroxicam ointment in o/w base promoted by azone

本文以改进的简单小室及离体的大鼠腹部皮肤研究了氮酮对吡罗昔康软膏体外释放的促进作用。处理组含氮酮浓度分别为1,2,3%,对照组不含氮酮。吡罗昔康的透皮吸收率分别为21.29,40.85,19.28,12.10%。经统计学 F 检验和 Q 检验表明:含2%氮酮处理组与对照组的透皮吸收率有显著性差异。

To increase the percutaneous absorption ofpiroxicam in o/w ointment,the influence of azoneat 0,1,2,3% levels was tested respectively.Isolat-ed rats' abdominal skin was used to compare withmodified simple cell as experimental apparatus.Itwas found that the addition of 2% azone is the op-timal percentage to drug release.The release datawere evaluated statistically by one-way analysis ofvariation.