氨苄青霉素在腹膜透析患者中的药代动力学研究

Pharmacokinetics of ampicillin in patients undergoing peritoneal dialysis

本文采用荧光分析法对8例腹膜透析患者应用氨苄青霉素后在透析液和血清中的药代动力学作了研究。结果显示:氨苄青霉素在腹膜透析液中能迅速被腹膜吸收。腹膜透析液中氨苄青霉素的半衰期为1.6±0.1h;放置4h 后的吸收率为81.0%;在人体中的分布客积为12.9±1.8L;停药后,氧苄青霉素在血清中的半衰期为55.9±9.9h。

Pharmacokinetic study of ampicillin wasmade in 8 patients with severe renal failure main-tained by continuous ambulatory peritoneal dialy-sis.The concentrations of ampicillin in serum anddialysate were measured by fluorometric assay.Theresults showed that the drug was rapidly absorbed,the elimination half-life(T(1/2))of ampicillin indialysate was 1.6±0.1h,and about 81% of thedrug administered was absorbed by the peritoneumafter 4 hours.The volume of distribution(V_d)was12.9±1.8L,and T(1/2) in serum 55.9±9.9h.