可乐定预防气管插管时心血管反应的研究

Protective Effect of Clonidine on Cardiovascular Responses to Endotracheal Intubation

目的 :在 30例择期手术的全麻患者中 ,观察术前口服可乐定 4～ 5 μg/kg ,预防气管插管时心血管反应的效果。方法 :30例患者随机分为实验组 (Ⅰ组 ) :术前口服可乐定 4～ 5 μg/kg ;对照组 (Ⅱ组 ) :不给可乐定。比较两组间给药前后 ,插管时和插管后 0、2、5min的心率、收缩压和Rpp值。结果 :插管时及插管后实验组心率、收缩压稳定 ,而对照组以上指标显著升高 (P <0 0 1) ,插管后对照组Rpp值也显著高于实验组 (P<0 0 1)。结论 :口服可乐定 4～ 5 μg/kg可有效的预防气管插管时的心血管反应。

Objective:To ob serve the protective effect of clonidine on cardiovascular responses to endotrachea intubation in 30 patients underwent selective surgeries with oral clonidine 4 to 5 μg/kg. Method: 30 patients were randomly divided into two groups:Experiment group (group Ⅰ,n=15,with oral clonidine 5μg/kg preoperanve) and control group (groupⅡ,n=15,without cbnidine ).The Heart rate,systolic pressure and RPP of two groups were obserred pre and post medicine,before and after 0,2,5 min of endotracheal intubation,then compared them. Results: The Heart rate and systolic pressure during and after intubation remained stably in group Ⅰ,but increased significantly in groupⅡ( P <0.01).Rpp was significantly higher in group Ⅱthan in group Ⅰ( P <0.01). Conclusion: Clonidine 4 to 5 μg/kg P.O.preoperative can validly prevent cardiovascular responses to endotracheal intubation.