田基黄注射液对小鼠醋氨酚肝脏毒性的保护作用

Protective effects of Hypericum japonicum Thunb.against acetaminophen hepatotoxicity in mice

醋氨酚中毒小鼠肝内 GSH 含量减少,微粒体 GST 活性降低,MDA、SGPT 和 SGST显著增加。小鼠 ip 田基黄8,15g/kg×10d,qd 后,使醋氨酚中毒小鼠 SGPT 和 SGST 活性恢复正常,肝内 GSH 含量明显升高,且呈剂量依赖性。上述剂量的田基黄对肝微粒体 GST 活性也具有保护作用。田基黄 15g/kg 可抑制醋氨酚中毒小鼠肝 MDA 的生成和 LTG 的形成。

The protective effects of Hypericum japonicumThumb.(HJT)against acetaminophen hepatotoxici-ty were studied in mice.After treatment with ac-etaminophen,SGPT,serum glutathione S-trans-ferase(SGST)and malonaldehyde(MDA)were sig-nificantly increased,hepatic GST content was de-pleted and microsomal GST activity was reduced.The high SGST,SGPT levels and decreased hepaticGST content returned to almost normal after HJTip 8,15g/kg qd×10d in acetaminophen intoxi-cated mice.The effects were dose-dependent.At the same time,the decreased microsomal GST increasedby the above doses of HJT.The production of lipidperoxide and triglyceride in injured liver tissue wasalso inhibited at 15g/kg HJT.