线粒体DNA与肿瘤、辐射生物效应和衰老关系的研究现状

The current status of studies on mitochondrial DNA with tumor, radiation biologi,cal effects and aging

线粒体是机体的重要能量加工厂,线粒体DNA是惟一的核外遗传物质,因此,线粒体在维持生物个体正常生理功能方面起着非常重要的作用。研究表明,线粒体DNA突变和缺失在许多疾病发生过程中起着非常重要的作用。概述了线粒体DNA在肿瘤、辐射生物效应及衰老等领域的研究现状,以期推进放射医学领域中线粒体DNA的应用研究。

The mitochondria plays a very important role in sustaining the normal physiological func,tion, because it is the center of energy making and mitochondrial DNA (mtDNA) is the only genetic material outside the nuclear. The result of studies showed that many diseases have a close relationship with mtDNA mutation and deletion. This article reviewed the current status of research on mtDNA with tumor, radiation biological effects and aging, in order to initiate the application study of mtDNA in the cir,cle of radiation medicine.