注射用七叶皂苷钠中七叶皂苷钠A和B的含量测定

Comparative study on quality of Sodium Aescinate for injection of different manufacturer

目的 :对北京市场上的注射用七叶皂苷钠进行含量测定 ,为控制产品质量提供依据。方法 :依据国家标准 ,采用酸碱中和滴定法测定注射用七叶皂苷钠中总皂苷含量 ,同时采用高效液相色谱法测定七叶皂苷钠A和七叶皂苷钠B的含量。结果 :不同厂家的样品中总皂苷含量均符合国家标准规定 ;而七叶皂苷钠A和七叶皂苷钠B的含量存在差别。结论 :国家标准实施后 。

AIM: To determine the contents of Sodum Aescinate for Injection in Beijing market in order to provide the basis for quanlity control. METHODS: According to national criterion, total aescinate is determinted by acid base titration. The contents of sodium aescinate A and sodium aescinate B in products are determined by HPLC. RESULTS: The total aescinate content in samples of the different manufactures are accord with national criterion, but the contents of sodium aescinate A and sodium aescinate B in products are different. CONCLUSION: After national criterion was carried into practice, the contents of sodium aescinate A and sodium aescinate B in products were up to standard.