溶石冲剂抗炎、镇痛、利尿作用的药效学试验

Anti-inflammatory,analgesic and diuretic actions of litholytic granule

目的 考察溶石冲剂在抗炎、镇痛、利尿方面的药效作用。方法 抗炎作用采用小鼠耳肿胀法 ,镇痛作用采用醋酸扭体法 ,利尿作用采用大鼠代谢笼法。结果 溶石冲剂高、中、低剂量能明显降低二甲苯所致小鼠耳廓肿胀度 ,明显抑制醋酸致小鼠的扭体反应 ,6h内能明显增加大鼠排尿量 ,与空白组比较具有显著性差异 (P <0 .0 5 )。结论 溶石冲剂具有明显的抗炎、镇痛、利尿的作用。

OBJECTIVE To investigate the anti-inflammatory, analgesic and diuretic actions of litholytic granule. METHOD The anti-inflammatory actions were investigated by the method of xylol induced auriclate swelling in mice. The analgesic actions were investigated by the method of acetic acid induced body-twisting in mice and the diuretic actions were investigated by the method of metabolism cages in rats.RESULTS Litholytic granule (37.20g·kg -1 ,24.80g·kg -1 ,12.40g·kg -1 )inhibited the mouse auriclate swelling induced by xylol and decreased the frequency of body torsion induced by acetic acid,also Litholytic granule (17.4g·kg -1 ,11.6g·kg -1 ,5.8g·kg -1 )increased the rat urinary output within six hours, which had marked difference compared with these of the control group (P<0.05).CONCLUSION litholytic granule has obvious anti-inflammatory, analgesic and diuretic actions.