卡介苗素治疗慢性乙型肝炎疗效分析

Clinical analysis of the treatment of E-BCG for the chronic hepatitis B

目的 观察卡介苗素对慢性乙型肝炎的治疗效果。方法 慢性乙型肝炎轻、中度患者 5 8例 ,其中治疗组 30例 ,对照组2 8例 ,两组基础治疗相同。治疗组加用卡介苗素 ,每次 1.0mg肌注 ,隔日 1次 ,疗程 6个月 ,观察两组肝功能 (ALT ,AST)和乙肝病素标志 (HBV M)的变化。结果 治疗组的HBeAg、HBV DNA阴转率分别为 4 0 .7%和 4 4 .4 % ,与对照组的 16 .0 %和 15 .4 %比较 ,差异均有显著意义 (P <0 .0 5 )。ALT复常率两组无显著性差异。结论 卡介苗素对乙肝病毒的复制有抑制作用 ,可用于慢性乙型肝炎的临床治疗。

OBJECTIVE To study the curative effects of Extra-Bacille Calmette-Guerin(E-BCG)on chronic hepatitis B. METHOD 58 patients with chronic hepatitis B(early or intermediate) were divided randomly into two groups the treatment group and control group. The treatment group (n=30) was injected 1.0mg E-GCG every other day, both of the groups were given same basic cure in order to observe the variation of ALT, AST and HBV-DNA after 6 month cure. RESULTS The disappearance rate of HBeAg and HBV-DNA in the experimental group were 40.7% and 44.4%, while they were 16.0% and 15.4% in the control group, there was significant difference between two groups(P<0.05). No significant difference of recovery rate of ALT between two groups was found.CONCLUSION As a drug to cure chronic hepertitis B, E-BCG is safe, low expensive and efficient.