肝细胞生长素治疗慢性活动性肝炎临床研究

STUDY ON HEPATOCYTE GROWTH FACTOR IN THE TREATMENT OF CHRONIC ACTIVE HEPATITIS

本文用肝细胞生长素(Hyratocyte Growth Factor,HGF)治疗40例慢活肝患者,对照组20例用强力宁治疗。结果治疗组血胆红素降至15.1±6.5μmol/L,对照组降至51.3±28.9μmol/L,治疗组优于对照组(P<0.01)。治疗组SGPT降至44.9±18.2u,对照组降至143.3±216.1u,差异显著(P<0.01)。治疗组的乏力、食欲不振、腹胀、肝区痛、肝大等症状与体征的消退或改善优于对照组。

Hepatocyte growth factor (HGF) was purified from weanling pig liver, The parer reported the results of using HGF to treat patients with chronic active hepatitis (CAH). Forty cases with CAH were treated by HGF.Twenty cases were treated by peplin.The results showed that bilirubin in treatment group decreased from 83.6±57.1μmol/L to 15.1±6.5μmol/L. Bilirubin in control group decreased from 82.5±39.3μmol/L to 51.3±28.9μmol/L. The difference of two groups is significant (P<0.01). SGPT in treatment group decreased from 420.3±384.6u to 44.9±18.2u.SGPT in contol group decreased from 411.1±384.6u to 143.3 ±216.1u.Treatment group is better than control group (P<0.01). Anorexia, asthenia, abdominal distension, ache in the right hypochondrium, hepatemegaly in treatment group were more like to improve than in control group.