三种止血材料对兔肝脏创伤止血效果的观察

Hemostatic effects of three types of hemostatic agents on hepatic trauma in rabbits

目的 通过比较明胶纤维网 (gelatinfleece ,GF)、氧化纤维素 (oxidizedcellulose,OC)和明胶海绵(gelfoam ,GL)对兔肝脏创伤的止血效果及周围组织反应 ,为其临床应用提供参考依据。方法 采用预制模板制成兔肝损伤出血模型 ,定量检测明胶纤维网 (GF)、氧化纤维素 (OC)及明胶海绵 (GL)的止血时间、出血量 ,并在不同时间点 ,局部取标本观察组织吸收及反应。结果 GF止血时间为 (0 .5 8± 0 .2 )分钟 ,出血量为(0 .30± 0 .1 9)ml与OC、GL比较有显著差异 (P <0 .0 5 ) ,对组织的反应较轻 ,8周时即可大部分吸收。结论 明胶纤维网是一种止血效果好、组织反应轻。

Objective To study the hemostatic effects of topical hemostatic agents: gelatin fleece (GF),oxidized cellulose (OC) and gelfoam (GL) on hepatic trauma in rabbits,and histological changes induced by 3 topical hemostatic agents.Methods Three types of hemostatic agent were used in a uniform model of hepatic trauma of rabbit. The blood loss and time to hemostasis were accurately recorded. The materials were left in situ and animals were killed between 1 day and 8 weeks later to examine speed of absorption and histological changes of hemostatic agents.Results GF stopped bleeding more rapidly than GL or OC,and was absorbed almost completely at 8 weeks,with little histological changes.ConclusionGF is an absorbable material with better hemostatic effects and little histological changes.