血管内皮生长因子在支气管肺泡细胞癌中的表达及意义

Expression of vascular endothelial growth factor and its significance in pulmonary bronchoalveolar carcinoma

目的 研究VEGF表达与支气管肺泡细胞癌临床病理特征之间的关系 ,探讨其在支气管肺泡细胞癌恶性生长中的意义。方法 应用免疫组织化学染色 ,检测 3 8例支气管肺泡细胞癌组织与正常肺组织标本中VEGF的表达水平及微血管密度 (MVD) ,并进行比较。结果 支气管肺泡细胞癌组织中VEGF阳性率 ( 73 .68%,2 8/ 3 8)和MVD( 63 .81± 19.2 6)均明显高于正常肺组织 ( 0及 18.44± 6.5 3 ) (P <0 .0 0 5 ,P <0 .0 0 1) ;VEGF表达水平、MVD分别与支气管肺泡细胞癌原发肿瘤大小 (P <0 .0 5 ,P <0 .0 5 )、淋巴结转移 (P<0 .0 2 5 ,P <0 .0 5 )及TNM分期 (P <0 .0 5 ,P <0 .0 5 )均有密切关系。与VEGF( -)者相比 ,VEGF( +)者支气管肺泡细胞癌组织中MVD显著增高 (P <0 .0 5 )。结论 VEGF表达与支气管肺泡细胞癌的临床病理特征密切相关 ,可能是促进支气管肺泡细胞癌恶性生长的重要因子。

Objective To study the relationship between the vascular endothelial growth factor (VEGF) and the clinicopathological characteristics of the patients with pulmonary bronchoalveolar carcinoma, and to research the possible role of VEGF in the malignant growth of pulmonary bronchoalveolar carcinoma. Methods The expression of VEGF and MVD were detected in 38 pulmonary bronchoalveolar carcinoma and 20 normal lung tissues by immunohistochemical method. Results The positive rate of VEGF expression (73.68%,28/38) and MVD (63.81±19.26) in pulmonary bronchoalveolar carcinoma tissues were both remarkably higher than those in normal lung tissues (0, 18.44±6.53)( P<0.005,P <0.001). The positive rate of VEGF expression was significantly related to the size of tumor ( P <0.05), lymphatic metastasis ( P <0.025) and TNM stage ( P <0.05), and so did the MVD ( P <0.05, P <0.05, P <0.05). MVD was remarkably higher in VEGF (+) carcinoma tissues than that in VEGF (-) carcinoma tissues ( P <0.05). Conclusion VEGF correlates with the clinicopathological characteristics of pulmonary bronchoalveolar carcinoma. It may play an important role in the development of pulmonary bronchoalveolar carcinoma.