摘要
增生性玻璃体视网膜病变 (PVR)是裂孔源性视网膜脱离手术失败最常见的原因。研究结果表明 ,PVR是视网膜脱离手术后的创伤愈合反应。随着视网膜的创伤 ,活化的视网膜色素上皮细胞 ,胶质细胞 ,纤维母细胞等增殖、迁移 ,与细胞外间质共同形成了PVR膜而导致牵引性视网膜脱离。就PVR的治疗而言 ,早期在于控制炎症 ,中期主要是抑制细胞增殖 ,晚期着重于防止纤维化的形成。着重就PVR的危险因素、临床分类、病理、手术处理以及最新的药物治疗进展做综合归纳。
Proliferative vitreoretinopathy(PVR)is well recognized complication of serious ocular trauma and rhematogenous retinal detachment.Great efforts have been made to better understand and manage this complication.Basic research showed that PVR is a wound healing response in the specialized tissue of retina and vitreous.Retinal injury activates RPE cells to proliferate and migrate into subretinal space,alone and within extracellualr matrix combined with glial cell,fibroblast,and inflammatory cell to form a membrane on the surface of retina and in the vitreous,which result in tractive retinal detachment.The sequence of events with PVR treatment would be to control inflammation reaction in the first phase,and the secondary phase to inhibit cell proliferation and the third is to prevent scar formation.Some risk factors,clinical classification,pathology,advanced medical treatment and surgical managements for various degree of PVR are discussed.
出处
《眼科研究》
CSCD
北大核心
2004年第2期216-220,共5页
Chinese Ophthalmic Research
