缺氧对P物质、降钙素基因相关肽舒血管作用的影响

Effect of hypoxia on vasodilation induced by substance P (SP) and calcitonin gene-related peptide (CGRP)

本文采用兔离体动脉(肾动脉,股动脉和基底动脉)浸浴实验。结果表明,缺氧可抑制P物质和降钙素基因相关肽的舒血管作用,并且缺氧对降钙素基因相关肽舒血管作用的影响较大。三种动脉比较,缺氧对基底动脉反应性的影响最为显著。

In this paper, isolated rabbit arteries (renal artery, RA; femoral artery, FA; basilar artery, BA) were used to study the effect of hypoxia on vasodilation induced by substanc P (SP) and calcitonin gene-related peptide (CGRP). The results showed that hypoxia caused a marked decrease of the arteries, response to SP(10^(-7)mol/L) and CGRP(2.8×10^(-9)mol/L). Repeated hypoxia even resulted in a complete disappearance of response. On the second hypoxia, CGRP (2.8×10^(-9)mol/L) induced vasodilation on BA was banished. On the third hypoxia, vasodilation induced by CGRP(2.8×10^(-9)mol/L) on FA and that induced by SP(2×10^(-9)mol/L) on BA were banished, and CGRP(2.8×10^(-9)mol/L) induced a lesser extent of vasodilation on RA. At the fourth time, SP(10^(-7) mol/L) -induced vasodilation of FA disappeared, and that on RA was small. At the fifth time, the effect of SP(10^(-7)mol/L) on RA was nearly banished. It is concluded that the effect of hypoxia on CGRP-induced vasodilation is stronger than that on SP-induced vasodilation, and the effect is most pronounced on the BA.