感染性休克大鼠血管反应性降低与血管内皮关系的初步探讨

Endothelium Contributes to the Decreased Aortic Contractility in Response to Norepinephrine in Experimental Septic Rats

外周血管阻力下降是感染性休克血压下降的关键因素之一。它可因各种舒血管物质释放增加所引起,亦可能与血管对缩血管物质的反应性下降有关。临床观察发现,感染性休克病人对去甲肾上腺素的反应减弱。体内、外动物实验也提示,感染性或内毒素性休克时,去甲肾上腺素的血管收缩效应减弱。感染性休克时血管对缩血管物质反应性减弱的机制目前仍不十分清楚。本实验复制大鼠腹膜炎休克模型,观察离体主动脉环对去甲肾上腺素反应性的变化,并分析血管内皮在血管反应性改变中可能具有的作用。

The responses to norepinephrine of thoracic aortic rings from septic and sham operated rats were compared. Rings with endothelium taken from septic rats manifested significantly lower maximal contractile response to norepinephrine (575±46.1 mg) in comparison with sham operated tissues (775±54.7 mg). Tissues without endothelium showed no significant difference. The results suggest that the diminished responsiveness to norepinephrine of the thoracic aorta in septic rats is mediated, at least in part, by vascular endothelium.