两性霉素B脂质体腔内注射治疗念珠菌性肝脓肿

Intra-abscess injection of liposomal amphotericin B to treat liver abscess due to Candida albicans

应用两性霉素B脂质体(抑霉泰,L-AMB)脓腔内注射治愈1例白念珠菌引起的肝脓肿。患儿男,12岁。因外伤手术后发现右肝前叶脓肿入院。先后行11次肝脓肿穿刺液真菌镜检和培养,证实为白念珠菌感染。在超声引导下脓腔内注射L-AMB,每周2次,首次0.8mg,以后依次为1.0、2.0、3.0、4.0mg,共注射9次,总量30.8mg。治疗后病情迅速好转,患者经脓肿穿刺液真菌镜检、培养转阴后出院。随访3年,未见复发。

A rare case of liver abscess due to Candida albi cans was cured with intra-abscess injection of liposomal am pho-tericin B(Amphotec).A12-year-old boy was admitted because an abscess of the right lobar in his liver developed after an in jury operation.The abscess acupuncture was performed for11times.Abscess fluid was examined and the in fection of Can-di da albi cans was confirmed by microscopy and culture examinations.The antifungal treatment was given by in tra-ab scess in-jection of liposomal amphoterin B twice a week under the direction of B ultrasonography.The first dose was0.8mg,and then the next dosage was increased to1.0,2.0,3.0and4.0mg,respectively.The total injection times were9and the total dosage was30.8mg.The abscess condition got better quickly,and the negative identification of abscess fluid was ob tained by mi croscopy and cul ture examinations.The patient was cured without recurrence through three-year follow-up.