小剂量生长抑素激动剂SMS201-995对正常成人胆囊收缩功能的影响

Acute Effect of Small Dosages of Somatostatin Analogue SMS201-995 on Gallbladder Contractility in Normal Adults

本文作者以脂餐试验结合B超声检查,首次观察到6例正常人每隔1周皮下注射生长抑素激动剂SMS 201-995(SMS)50、25、12.5及5μg后,胆囊收缩功能被明显抑制至少6h。提示在SMS临床应用中要注意其抑制胆囊收缩功能的副作用;同时,为胆囊结石形成机理的研究提供了有益的线索。

Recently, a long-acting somatostatin analogue, SMS201- 995(SMS), has been developed and extensively investigated.It has been proved to be remarkably effective in treating many diseases, including active acromegaly. We observed the effect of SMS on gallbladder contractility in normal adults using the fatty meal test. Our results show that gallbladder contractility was inhibited significantly for 6 hours after the subcutaneous injection of SMS indosages of 50, 25, 12.5, and 5μg. We conclude that it is not practical to avoid gallbladder disfunction during long-term SMS treatment by decreasing the dosages of SMS.