摘要
在白血病和再生障碍性贫血(再障)发病情况调查基础上,采用基于全人群1:2配对的病例对照研究,对新发白血病1257例和再障339例进行危险因素调查.按白血病和再障的类型对危险因素进行条件Logistic回归模型分析,平衡混杂因素后,发现与M2a有关的危险因素有X线、解热镇痛药、苯类物及农药化肥,乙双吗啉类药为高度可疑因素;与M3有关的因素有氯(合)霉素;与M5有关的因素有X线;与其它急性非淋巴细胞白血病(ANLL)亚型有关的因素有抗风湿类药;与急性淋巴细胞白血病(ALL)有关的因素有氯(合)霉素、抗风湿药及直系亲属患肿瘤史;与慢性粒细胞白血病(CML)有关的因素有X线与病毒性肝炎。与急性再障(AAA)有关的因素有解热镇痛药与病毒性肝炎。与慢性再障(CAA)有关的因素有X线。单因素分析表明,与慢性淋巴细胞白血病(CLL)有关的因素有氯(合)霉素及苯类药。
Based on the incidence survey of leukemia and aplastic anemia (AA) from 1986 to 1988, Case control studies (1257 new leukemia cases and 339 new AA cases) were carried out according to the type of leukemia and AA in order to beffer understand the epidemiologic characteristics of the diseases. Controls were matched randomly (age, sex and ethnic group) from the same population. The deta were analyzed with the conditional Logistic multiregression model and calculated on an IBM-PC/XT. The risk factors of M2a were found to be X-rays, autipyretics, benzene, pesticides and bimolane; that of M3 was chlor-amphenicol; that of M5 was X-rays; and that of other ANLLs was phenylbu-tazone. The risk factors of ALL were choloramphenicol, phenylbutazone and family members with cancer; those of CML were X-rays and hepatitis-, those of CLL were chloramphenicol and benzene;those of AAA were antipyretics and hepatitis; and that of CAA was X-rays.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1992年第3期185-189,共5页
Acta Academiae Medicinae Sinicae
关键词
白血病
再生障碍贫血
leukemia anemia, aplastic factor analysis, statistical
