甲状腺激素对脑发育的重要影响

Essential role of thyroid hormones in brain developm ent

甲状腺激素 (TH)在哺乳类动物脑发育中具有重要的作用。孕母亚临床甲状腺功能减退症(甲减 )可造成胎儿神经发育受损 ,对孕妇作甲减筛查是值得推荐的做法。

Thyroid hormones (TH) play an imp or tant role in the development and maturity of the mammalian brain. Maternal TH de ficiency, even subclinical hypothyroidism, leads to poor neurodevelopment of the fetus. Screening of pregnant women for hypothyroidism is recommended. Identific ation of the TH-responsive genes in the developing brain and investigation on t heir functions are helpful to provide insights into the molecular mechanisms by which TH influence brain development.