暗示或/和咖啡因对30h睡眠剥夺下简单反应时和知觉加工的影响

Effects of placebo implication and/or caffeine on healthy male subjects' simple reaction time and perception during 30 h of sleep deprivation

目的 :研究安慰剂暗示或 /和咖啡因对睡眠剥夺条件下简单反应时和知觉加工的影响 ,提出合理有效的对抗睡眠剥夺的用药策略 .方法 :被试自身前后对照 ,实验分 5次进行 ,每次进行 30h睡眠剥夺 ,其间安排 5组简单反应时测验和Stroop测验 .第 1次 ,为完全睡眠剥夺 (对照 ) .另外 4次实验被试分别在特定时间服用安慰剂 2 0 0mg、咖啡因 2 0 0mg、咖啡因 4 0 0mg、咖啡因和安慰剂各 2 0 0mg.通过强调咖啡因的兴奋作用给予被试心理暗示 .结果 :Stroop测验中 ,服用咖啡因 4 0 0mg以及咖啡因和安慰剂各 2 0 0mg的单位时间正确率 (correctrateofpersecond ,CRPS)明显大于对照 (P <0 .0 5 ) ;咖啡因 4 0 0mgCRPS大于安慰剂 2 0 0mg (P <0 .0 5 ) .在简单反应时测验中 ,5次实验之间的CRPS无差异 (P >0 .0 5 ) .结论

AIM: To study caffeine and/or placebo implication as countermeasures during sleep deprivation (SD). METHODS: A double blind, within subjects and counter balanced design was employed and five trials were conducted. Subjects were exposed to a 30 hour SD in each trial. No medicine was administrated in control trial while placebo 200 mg, caffeine 200 mg, caffeine 400 mg, and the combination of caffeine (200 mg) and placebo (200 mg) were administered, respectively in the other four trials. Simple reaction time test and Stroop test were used to assess the perception. RESULTS: In Stroop test, the correct rate per second (CRPS) of caffeine 400 mg and the combination of caffeine and placebo was higher than that of the control trial ( P <0.05). Compared with that of placebo 200 mg, CRPS of caffeine 400 mg was higher ( P <0.05). In simple reaction time test, there was no significant difference among the five trials ( P >0.05). CONCLUSION: Caffeine and placebo implication are very effective countermeasures on sleep deprivation.