肺动脉高压大鼠血浆肾素—血管紧张素、精氨酸加压素的改变

The Changes of Plasma Renin Angiotensin and Arginine Vasopressin in Pulmonary Hypertension Rats

观察心外左向右分流(LRS)、低压性缺氧(HH)及分流附加低压性缺氧(SHH)所致肺动脉高压(PH)大鼠血浆肾素活性(RA)、血管紧张素Ⅰ(AⅠ)、血管紧张素Ⅱ(AⅡ)浓度及AⅠ转变为AⅡ的比率和精氨酸加压素(AVP)的改变。结果LRS组及SHH大鼠RA呈升高趋势,但与对照组比较无显著差异(P>0.05);HH组无改变。LRS组AⅡ浓度显著高于对照组(P<0.05),AⅠ及AⅡ/AⅠ亦呈升高趋势,但未达显著差异(P>0.05);而HH及SHH组较LRS组降低,尤以HH组为著。LRS大鼠AVP显著升高(P<0.05);其他组也呈升高趋势,但未达统计学显著意义(P>0.05)。本文对体液因素在PH形成中的作用进行了分析。

The plasma renin activity (RA), the concentration and the ratio of angi-otensin (AⅠ) conversion into angiotensin Ⅱ (AⅡ), and arginine vasopressin(AVP) level were observed in Wistar rats with pulmonary hypertension (PH) induced by extracardiac left-to-right shunting (LRS), hypobaric hypoxia (HH) and shunting plus HH (SHH). In comparison with normal control rats, RA in LRS and SHH rats showed an increasing trend, although no statistical significance appeared (P>0.05). No change occurred in HH rats. The concentration and ratio of AⅠ conversion into AⅡ were significantly increased in LRS rats(P<0.05), but decreased in HH and SHH rats (more markedly in HH rats). AVP increased significantly in LRS rats,and also showed an increasing trend in HH and SHH, but no significance was found (P>0.05).The action of humoral factors in PH formation was discussed.