血清肿瘤相关糖蛋白72测定对恶性肿瘤诊断价值的初步探讨

The Value of Serum Tumor-associated Glycoprotein 72 (TAG 72) in the Diagnosis of Malignancies

不断寻找和筛选新的肿瘤相关抗原并对其诊断价值作出客观准确的评价,是提高恶性肿瘤诊断水平的重要途径。肿瘤相关糖蛋白72(tumor-associated glycoprotein 72,简称TAG 72)是近年从乳腺癌转移细胞株制备出的肿瘤标志物,它是一种高分子量、粘蛋白样物质,据报道此抗原在结肠癌、胃癌、胰腺癌、卵巢癌和肺癌病人血清及组织含量均可见增高。本文测定了正常人以及良性疾病和恶性肿瘤病人的血清TAG72浓度共329例,对其在恶性肿瘤的诊断价值做一初步探讨。

Serum TAG 72 concentrations of 110 normal subjects, 110 patients with benign diseases and 109 with malignant diseases were determined by a solid phase radioimmunoassay. Its levels in normal subjects were 1.6±1.5 u/ml (X ± SD, range 0-8.2 u/ml) and the cut-off limit was set at 4.6 u/ml. The positive rates in benign and malignant patients were 5.5% and 48.6%, respectively. Among the malignancies, 80.0% of ovarian and 63.6% of colon carcinomas had positive test results. The specificity for differentiating malignancies from benign diseases was 94.5% and the accuracy of diagnosis was 71.7%. The present study indicates that TAG 72 as a tumor marker is helpful in the diagnosis of malignancies.