呋喃唑酮胃漂浮控释片的研究

STUDY ON FURAZOLIDONE FLOATING SUSTAINEDRELEASE TABLET IN STOMACH

制备了呋喃唑酮胃内滞留漂浮型缓释片剂(简称 Fu-HBS)。它以零级及 Higuchi 方式在体外释药。γ-闪烁照相结果表明,Fu-HBs 在人胃内滞留时间为4～6h,明显长于普通片(1～2h)。实验表明,Fu-HBS 片稳定,贮存期暂定两年。初步试验表明,其对幽门弯曲菌清除率为70.0%,胃窦粘膜病理炎症的好转率为75.0%。

Furazolidone floating sustained-release tablet(Fu-HBS)was pre-pared.The drug was released in vitro according to zero-order kinetics and Higu-chi equation simultaneously.γ-Scintiphotography showed the residence time inthe stomach of Fu-HBS was 4～6h,which was much longer than that furazolidoneconventional tablets(1～2h).The effects of temperature and humidity on thestability of Fu-HBS were studied.The effect of Fu-HBS on Campylobacter pylori(CP)was examined through clinical trial.Negative rate of CP and improvementrate of inflammation in the gastric mucosa were 70.0%,75.0% respectively.