病毒性脑膜炎、脑炎脑脊液胆碱酯酶活性与血清病毒抗体的关系

The relationship between the activity of CHE in CSF and antibody in serum of viral meningitis,encephalitis.

目的 探讨病毒性脑膜炎、脑炎患儿脑脊液胆碱酯酶 (CHE)的活性和血清抗体的关系 ,为临床提供诊疗依据。方法 采用终点法及速率法进行生化分析 ,ELISA法进行血清抗体检测。结果 小儿病毒性脑膜炎、脑炎的脑脊液中CHE的活性、蛋白与无机磷的含量有显著改变 (P <0 .0 5 )且CHE的活性与蛋白、无机磷的含量有相关性 ;患儿血清中I型副流感病毒(PIV)阳性率为 2 4 .5 % ,腺病毒 (ADV)为 18.0 % ,再次为柯萨奇病毒、呼吸道合胞病毒、乙脑病毒、甲型流感病毒。结论 ①小儿病毒性脑膜炎、脑炎的脑脊液中CHE的活性明显增高 ,提示小儿病毒性脑膜炎、脑炎将会影响胆碱能神经元的功能 ;②血清抗体不同 ,脑脊液CHE的活性升高不同。在所测的几种血清抗体中 。

Objective Studying the relationship between the activity of CHE in CSF and antibody in serum of viral meningitis,encephalitis in order to supply the evidence for doctor.Methods Characters of biochemistry were determined by Rat-mete and Ending-method , antibody was determined by ELISA. Results The activity of CHE and the concentrations of Protein and P in CSF were found to be significantly higher than controls (P< 0.05) and CHE showed high correlation with protein, middle correlation with P. The positive rate of PIV is 24.5%, ADV is 18.0%, following CVB, RSV, encephalitis B virus, IVA.Conclusion (1) The activity of CHE in CSF were found to be significantly higher than controls means all virus will make badly effect on cholinergic neuron. (2)The affection of each virus was different and it was most serious what caused by CVB in all.