摘要
目的 探讨环氧合酶 2 (COX 2 )在骨肉瘤中的表达及其意义。方法 应用免疫组织化学染色研究人骨肉瘤组织、骨类肿瘤样病变 (骨纤维结构不良 )及正常骨组织中COX 2的表达 ,分析其表达差异性。结果 COX 2在正常骨组织中不表达 ,在骨肉瘤中表达阳性率为 6 7.7% ,骨纤维结构不良表达阳性率为 2 3.5 % ,后两者间的差异具有极显著性意义 (P <0 .0 1) ;在发生转移的骨肉瘤中COX 2表达阳性率为 82 .4 % ,明显高于未发生转移组 (5 0 .0 % ) ,两者差异有显著性意义 (P <0 .0 5 )。结论 骨肉瘤组织中存在COX 2的高表达 ,COX 2与骨肉瘤的发生发展有密切关系。
Objective To investigate the expression of cyclooxypenase 2 (COX-2) in osteosarcoma and its significance.Methods The expression of COX-2 in human osteosarcoma tissue, tumor-like lesion of bone (fibrous hyperplasia of bone) and in natural bone tissue was detected by immunohistochemistry.Results There was no expression of COX-2 in natural bone tissue. The positive rate of COX-2 expression was 67.7 % in osteosarcoma and 23.5% in fibrous hyperplasia of bone and the difference between them was very significant (P< 0.01). In the metastases and non metastases in osteosarcoma the positive rate of COX-2 expression was 82.4 % and 50.0 % respectively with the difference being significant (P< 0.05).Conclusion There was overexpression of COX-2 in human osteosarcoma. The expression of C0X-2 has a close correlation with osteosarcoma.
出处
《华中医学杂志》
2004年第2期109-110,共2页
Central China Medical Journal