摘要
以抗瘤酮 A_(10)和 AS_(2-5)为先导化合物,设计合成了15个谷氨酰胺的衍生物。初步抑瘤试验结果表明,化合物3、6、8、9和10对小鼠肉瘤 S180有较好的抑制作用,抑制率达30.3~64%.
Fifteen derivatives of glutamine were synthesized,with antineop-laston A_(10)and AS_(2-5) as leading compounds.The preliminary antitumor test showed that compound 3,6,8,9 and 10 demonstrated good inhibitory effect on mice S180,with inhibitory rate of 30.3~64% against antineoplaston A_(10) of 30%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1992年第6期255-258,共4页
Chinese Journal of Pharmaceuticals
关键词
谷氨酰胺
衍生物
合成
抗肿瘤
glutamine derivatives
synthesis
antitumor