婴幼儿肺炎心衰时cTnI的变化

Variation of cTnI on heart failure by bronchopneumonia in infants and young children

目的 探讨婴幼儿肺炎患儿血浆心肌肌钙蛋白I(cTnI)水平的变化。方法 分别用放射免疫法和全自动生化分析法测定了 90例婴幼儿肺炎循环血中cTnI及CK MB浓度 ,其中轻症组 5 0例 ,重症组 (肺炎合并心衰 ) 4 0例 ,并以 2 5例正常婴幼儿为对照组。结果 重症组血浆cTnI浓度明显高于轻症组及正常对照组 (P <0 0 1 ) ,且重症组cTnI敏感性为 82 % ,较CK MB敏感性 (5 7% )高 (P <0 0 5 )。结论 肺炎心衰患儿血浆cTnI浓度明显升高 ,cTnI可反映其心肌损伤 ,并可作为早期发现心肌损伤敏感而特异的指标之一。

Objective To investigate the level of plasma cardiac troponin Ⅰ(cTnI)concentration for the pneumonia infants with heart failure.Methods The concentrations of plasma cTnI and CK MB were measured by radioimmunoassay and automatic biochemical analysis respectively in 90 infants with pneumonia,(50 patients were moderate and 40 were severe with heart failure),25 healthy infants were selected as normal controls.Results the level of the plasma cTnI in 40 severe cases was significantly higher than that in 50 moderate cases and the control group ( P <0 01).The sensitivity of plasma cTnI in the severe cases was 82%,significantly higher than that of the CK MB ( P <0 05).Conclusion These data indicate that cardiac troponin I is increased in infants with pneumonia damage,plasma cTnI is one of the early sensitive and specific markers to diagnose myocardial damage.