摘要
以间甲基苯甲酸为起始原料,通过傅氏、溴代、氰化、水解反应制得3-苯甲酰苯乙酸,再经相转移催化甲基化生成2-(3-苯甲酰苯基)丙酸甲酯,直接水解合成酮洛芬,总收率54%。本法原料易得,工艺简单,各步收率均较好。
An improved synthesis of ketoprofen,involving Friedel-Crafts reac-tion,bromination,cyanation,hydrolysis,phasetransfer catalytic α-metbylationand hydrolysis,from m-toluic acid,in about 54% overall yield is described.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1992年第7期290-292,共3页
Chinese Journal of Pharmaceuticals
