摘要
采用固体分散技术,将硝苯啶制成舌下片。体外溶出、粘膜渗透试验及家兔给药后的血药浓度测定等证明,本片体外溶出快,粘膜透过量大,生物利用度高。
Nifedipine is a poorly water-soluble drug and possesses lowbioavailability when administered orally.In order to improve the bioavailabilityof its tablets,with the solid dispersion of nifedipine and PVP with 1:2 weight ratio,the sublingual tablets were prepared.In vitro,nifedipine was released from thetablets more rapidly than the conventional tablets,and in vivo study showed thatthe tablets had higher bioavailability.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1992年第7期304-307,共4页
Chinese Journal of Pharmaceuticals
关键词
硝苯啶
固体分散物
舌下片
nifedipine
solid dispersion
sublingual tablet
bioavaflability
PVP
mucosa
