HOEC活性酯法合成胞壁酰二肽类似物

SYNTHESIS OF MURAMYL DIPEPTIDE ANALOGS BY HOEC ACTIVE ESTER METHOD

用 N-羟基-1,4-桥氧-5-环己烯-2,3-二甲酰亚胺活性酯方法从游离 L-缬氨酸和 D-谷氨酸合成两个胞壁酰二肽类似物:壁缬二肽和壁缬二肽丁酯。两者免疫刺激活性强,能激活巨噬细胞的吞噬功能。

Two of the muramyl dipeptide analogs were synthesized fromD-glutamic acid,L-valine and protected N-acetylmuramyl acid,using N-hydroxy-1,4-epoxy-5-cyclohexene-2,3-dicarboximide(HOEC)as a coupling agent.They possessed strong immunostimulating activities in the preliminary in vitrotests