期刊文献+

丙硫氧嘧啶合成工艺改进 被引量:4

IMPROVED SYNTHESIS OF PROPYLTHIOURACIL
下载PDF
导出
摘要 丙硫氧嘧啶(1)为一种较好的甲亢治疗剂,我所以乙酰乙酸乙酯为原料,合成本品,投入生产。但由于总收率低,生产成本过高。为此,我们又对本品的合成工艺进行了研究,改用丙二酸二乙酯,增加了一步脱羧反应,并革除了要求较高的格氏反应,产品经一次精制即可符合中国药典85版标准。
作者 曹志荣
出处 《中国医药工业杂志》 CAS CSCD 北大核心 1992年第8期342-343,共2页 Chinese Journal of Pharmaceuticals
  • 相关文献

同被引文献12

  • 1汪敦佳.盐酸环丙沙星合成工艺的改进[J].中国医药工业杂志,1994,25(7):296-298. 被引量:20
  • 2Constantions D A, Ghada J C, Sotiris K H, et al. Synthesis and Characterization of (PTU) I2 and (CMBZT) I2 and Possible Implications for the Mechanism of Action of Anti- thyroid Drugs[J]. Eur J Inorg Chem, 2003, 1635-1640.
  • 3Okabe O, Fujiwara T, Yamagata Y, et al. Structure of a potent Anti-thyroid Drug , 6-Prooyl-2-thiouracil[J]. B Chem Soc Jpn, 1983, 56: 1543-1544.
  • 4Rownicka Z, Sulkowska A, Bojkoet B,et al. Binding of 6- propyl-2-thiouraeil to human serum albumin destabilized by chemical denaturants I J]. J Photo Ch Photo Bio, 2009, 97: 54-59.
  • 5Meng G, Chen F E, Erik D C, et al. Nonnucleo side HIV-1 Reverse Transcriptase Inhibitors: Part I. Synthesis and Structure-Activity Relationship of 1-Alkoxymethy1-5- alkyl-6-naphthylmethyluracils as HEPT Analogues [J]. Chem Pharm bull, 2003, 51(7): 779-789.
  • 6Thompson D, Kerry L, et al. Antiviral Pyrimidines. US, WO20010118367A2[P], 2010-10-14.
  • 7Pankovic Z, Jennifer K, Jennifer K, et al. Design and optimization of a series of novel 2-cyano-pyrimidines as cathepsin[J].Bio org Med Chem Lett, 2010, 20: 1524-1527.
  • 8Ismail M A H, Abozid KA M, A1-Ansary G H A, et al. Computer based drug design, synthesis and biological evaluation of new pyrimidinone derivatives linked to arylpiperazine and 2" -earbethoxy -biphenylylmethyl moieties as otl-adrenoceptor antagonists and angiotensin II.AT1 receptor antagonists[J]. Die Pharmazie, 2010, 65(11): 794-800.
  • 9马明华,纪秀贞,沈佰林,万平.盐酸环丙沙星合成工艺改进[J].药学进展,1997,21(2):109-111. 被引量:13
  • 10唐双宁.必须解决中国商业银行九大趋同问题[J].中国金融,2010(13):95-95. 被引量:5

引证文献4

二级引证文献30

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部