血管紧张素Ⅰ转换酶基因多态性与脑梗死的相关性研究

Association between angiotensin converting enzyme gene polymorphism and cerebral infarction

目的探讨中国人群血管紧张素Ⅰ转换酶 (ACE)基因插入 /缺失 (I/D)多态性和脑梗死的相关性。方法用聚合酶链反应 限制性片段长度多态性的方法检测 2 42例脑梗死和 2 83例正常对照的ACE基因多态性 ,多元Logistic回归模型分析其与脑梗死的相关性。结果经年龄、性别、饮酒、吸烟、文化程度、糖尿病、高血压调整后 ,ACE基因与脑梗死、高血压、糖尿病无显著相关 ;高血压导致脑梗死发病危险性显著增加 (OR =7 2 8,P =0 0 0 0 ) ;ACE基因ID/DD基因型和高血压对脑梗死的发生有明显交互作用 ,显著增加脑梗死的危险性 (交互作用系数 =1 62 ,OR =7 2 9) ,为 2型交互作用中的超相乘模型。结论ACE基因I/D多态性与脑梗死发病无相关性 ,但ACE基因ID/DD基因型和高血压对脑梗死有交互作用 ,增加脑梗死的危险性。

ObjectiveTo explore the association between angiotensin converting enzyme (ACE) gene insertion/deletion(I/D) polymorphism and cerebral infarction among Chinese people. MethodsThe ACE gene polymorphism was determined by PCR-RFLP in 242 patients with cerebral infarction and 283 controls. Multiple logistic regression was performed to explore the risk factors for cerebral infarction. ResultsAfter adjusting age, gender, alcohol drinking, smoking, education,history of diabetes mellitus and the primary hypertension, there was no significant association between ACE I/D polymorphism and cerebral infarction, either was hypertension and diabetes mellitus. The primary hypertension significanlly increased risk of cerebral infarction (OR=7.28, P =0.000). Both ACE ID/DD genotype and the primary hypertension showed a significant gene-environment interaction( r =1.62,OR=7.29), something as super multiplicative type 2 interaction. ConclusionAlthough ACE gene polymorphism is not risk factors of cerebral infarction, but ID/DD genotype had shown significant gene-environment interaction with primary hypertension in occurrence of cerebral infarcion.