血管紧张素转换酶基因多态性与冠脉病变严重程度的相关性研究

Relationship between angiotensin-converting enzyme gene polymorphism and the severity of coronary artery stenosis

目的 探讨血管紧张素转换酶 (ACE)基因I D多态性与冠心病及冠脉病变严重程度的关系。方法 对 12 2例冠心病患者进行冠状动脉造影 ,判定冠脉病变支数 (狭窄程度≥ 75 % )和危险记分。用聚合酶链式反应(PCR)技术检测病例组和 80例健康人群ACE基因多态性。结果 ACE基因型分布和等位基因频率在病例组和对照组间差异有显著性 ,病例组DD基因型 (38.5 % )和D等位基因频率 (5 5 % )显著高于对照组 (13.7% ,4 1% ;P <0 .0 5 )。冠脉病变支数和危险记分在ACE基因型间差异无显著性 (P >0 .0 5 )。结论 ACE基因多态性中DD型和D等位基因是冠心病发病的独立危险因素 ,但与冠脉病变严重程度不相关。

Objective To explore the relationship between angiotensin-converting enzyme(ACE) gene polymorphism and the severity of coronary artery stenosis. Methods One hundred and twenty two CHD patients underwent coronary angiography were selected to determine the number of affected coronary vessels(>75% stenosis) and coronary score. The insertion/deletion polymorphism of ACE gene was examined by means of polymerase chain reaction(PCR) in CHD patients and 80 control subjects. Results DD genotype and D allele of ACE were more frequent in CHD group than in control group( P <0.001). Neither the number of affected coronary vessels nor the coronary score differed between the ACE I/D genotypes( P >0.05). Conclusion DD genotype and D allele should be risk factors for CHD and MI in Chinese people from Zhongyuan area, and not be related to the severity of the coronary artery stenosis.