尼莫地平片的体外溶出度考察

Investigation on the Dissolution of Nimodipine Tablets

本文采用紫外分光光度法(λmax239±1nm)对国产三厂四批尼莫地平片进行体外溶出度测定。求得Td参数具有极显著差异(P<0.01)。各厂产品在30min内溶出均大于60%,并建议尼莫地平片溶出标准[以转篮法:转速100r/min,无水乙醇:水(3:7)作溶出介质,介质容积1000ml]为30min内溶出量不低于60%。

(Second affiliated Hospital, Hebei Medical College, Shijiazhuang, 050000) The dissolution of four batches of nimodipine tab. from three domestic pha- rmaceutical factories was determined with UV spectrophotometry (λ_max 239±1nm). It was found that the Td of these samples had very significant difference (p< 0.01). The release of nimodipine of all batches was more than 60% within 30min. We recommend that dissolution rate (rotating basket, 100r/min, Ethanol: H_(2)O=3: 7, 1000ml) of nimodipine tab. should not be less than 60% within 30 min.