麦迪霉素胶囊的生物利用度和药物动力学研究

Pharmacokinetics and bioavailability of medecamycin capsule

本文用反相快速柱高效液相色谱法测定血清中的麦迪霉素浓度。对12例健康受试者自身交叉口服600mg进口和国产的麦迪霉素胶囊后测定其血药浓度,计算药物动力学参数和相对生物利用度,麦迪霉素口服吸收表现为一房室模型,其进口和国产的药动学参数分别为:T_(1/2)77±28和76±27min;Ka0.23±0.28,0.15±0.19min^(-1);t_(PK)89±50和94±41min;C_(PK)0.20±0.09mg/L,0.18±0.07mg/L,相对生物利用度(F校正)为1.00±0.25。

The medecamycin concentraction in serum was determinated with reverse-phase speed analytical column. After oral administration of Japanese and Chinese med- ecamycin capsule 600mg, respectively, serum medecamycin level, pharmacokinetic parameters and comparitive bioavailability of the health colunteers were determ- inated. The result of estimation of the T_(1/2), Ka, T_(pk), C_(pk) had no difference. The result was T_(1,2) 77±28 and 76±26min, T_(pk) 89±50 and 94±41min, C_(pk) 0.20±0.09 and 0.18±0.07mg/L, Ka 0.23±0.28min^(-1) and 0.15±0.19min^(-1). The comparitive bioavailability was 1.00±0.25.