摘要
呋喃氟脲嘧啶(FT207)口服给药分布到直肠靶区的药物浓度低,影响对直肠癌的疗效。为此,我们设计一直肠栓剂,并伍用左旋咪唑及月桂氮(艹卓)酮(Azonc)等合理组方,经家兔直肠给药的药物动力学及组织分布研究证实,FT207血药浓度经时过程为二室模型。其分解产物5—FU血药浓度经时过程为一室模型,药物直肠浓集度显著高于其它组织,比口服相同剂量FT207片高数十倍(FT207)和数倍(5—FU),药物向正常组织的分布减少,对于提高直肠癌疗效降低毒副作用有重要意义。
The Plaema concentration of Ft-207 and 5-Fu Was meaSured With hight Perfovmance liquid chro-matography. The resuite showed that the plasma Concentration time course ot FT-207 Conformed to thetwo compartment model, and souc time-sand that of 5-Fu conformed to one compertment model the con-centration of FT-207 and 5-Fu in rectum wae eighty four times. highe respectivety using the suppeitoryThan that using FT-207 tables.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1992年第5期200-202,共3页
Chinese Journal of Hospital Pharmacy