重结晶法增加布洛芬生物利用度

Increasing the bioavailability of Ibuprofen by recrystalization

本文用不同浓度的泊洛沙姆(Polorxamer)溶液对布洛芬进行重结晶,并分别在人工胃液和肠液中进行溶出试验。结果表明,在5%的泊洛沙姆浓度下重结晶的布洛芬溶出速率最大。故选此重结晶的布洛芬溶出速率最大的进行家兔体内生物利用度实验。结果表明,溶出速率和生物利用度都存在着显著差异。

In this paper. The recrystalization of Ibuprofen in polorxamer solution was described. The highest dissolution rate of reerystalized Ibuprofen in 5% plorxamer solution was obtained. The bioavaildbillty was determined in rats. The bioavailability ofthe recrystalized Ibuprofen was higner than the uncnhnged drug.