内耳减压病豚鼠听力和耳蜗组织的病理变化

HEARING AND COCHLEAR HISTOPATHOLOGICAL CHANGES IN GUINEA PIGS WITH INNER EAR DECOMPRESSION SICKNESS

研究探讨了内耳减压病豚鼠皮层听觉诱发电位阈值、耳蜗火棉胶切片、酶组织化学和透射电镜观察的变化。结果表明,豚鼠内耳减压病导致听力损失,耳蜗广泛的病理损害.毛细胞琥珀酸脱氢酶活性降低。提出了加压治疗内耳减压病时配合改善微循环、增加能量供应等见解。

The inner ear decompression sickness in guinea pigs was studied with auditory electro-physiological test, histopathological, transmission electron microscopic and enzyme histochemical techniques. The animals with inner ear decompression sickness showed a significant increase in hearing threshold soon after decompression. Histopathological study demonstrated that cochlear bleeding into the fluid-filled spaces, degeneration of Corti's organ or both occurred in the animals. Transmission electron microscopy revealed an edematous cytoplasm and grossly distorted outer hair cell body. The decreased activity of succinic dehydrogenase was found by enzyme histochemistry. It is suggested that inner ear decompression sickness does cause severe damage to the cochlear system and that it is necessary to improve inner ear microcirculation for treating the inner ear decompression sickness in addition to recompression therapy.