摘要
本实验研究了人酸性成纤维细胞生长因子(haFGF)的体外神经营养作用。结果表明,haFGF在体外能明显促进鸡胚(E-8)脊髓组织神经突起的生长,并能明显改变新生大鼠脑星形胶质细胞的形态,使扁平、多角形紧密联接的细胞转化为具有纤维样突起的胶质细胞,同时对胶质细胞DNA合成也有一定促进作用。实验还证明,haFGF可增加体外培养新生大鼠海马神经元的存活,且大大增加神经元胞体体积及突起长度。
Neurotrophic effect of human acidic fibroblast growth factor (haFGF) in vitro was studied. The results showed that haFGF enhanced the neurite extension of chick embryo (E-8) spinal cord explants and the survival of neurons derived from newborn rat hippocampus. The body area and neurite length of hippocampal neurons were increased significantly by haFGF. The results also showed that haFGF could change the morphology of astrocytes in newborn rat brain and increase the DNA synthesis of neuroglial cells.
出处
《中国应用生理学杂志》
CAS
CSCD
1992年第2期102-105,共4页
Chinese Journal of Applied Physiology
关键词
神经营养
成纤维细胞
生长因子
haFGF
spinal cord explants
neuroglial cells
hippocampal neurons
neurotrophic effect
