盐酸艾司洛尔预防全麻气管插管心血管反应的临床研究

Effects of esmolol on cardiovascular reaction in p atients undergoing tracheal intubation

目的 探讨艾司洛尔对全麻气管插管心血管反应的预防作用。方法 患者 90例 ,随即分为 3组 ,每组 30例 ,组Ⅰ为艾司洛尔 1mg/kg:组Ⅱ为艾司洛尔 2mg/kg ;组Ⅲ为生理盐水 10ml。气管插管前分组用药。气管插管后 ,在避免刺激的条件下 ,分别在给药前、给药后、插管后 1,2 ,3,5及 10min ,监测并记录HR ,SBP和DBP ,测得数据进行统计学处理。结果 气管插管后 ,艾司洛尔 2mg/kg组的HR明显低于 1mg/kg组 ,而 1mg/kg组又低于对照组。BP各组间各时间段差异均无显著性。结论 艾司洛尔预防全麻气管插管引起的心动过速有效 ,且药效与剂量相关 ;预防气管插管引起的血压升高 ,效果不明显。

Objective:To probe into the prevention against th e effects of esmolol on cardiovascular reactions in patients undergoing trachea l intubation.Methods: 90 patients were divided into 3 groups ( 30 patients in each group )radomly. Group 1 took esmolol 1 mg/kg;Group 2 took esmolol 2 mg/kg;Group 3 took pumping brine 10 ml. Before the tracheal intubat ion,each group took medicine separately. After the tracheal intubation and und er the condition without stimulation,inspected and noted HR,SBP and DBP ,befo re and after the patients took madicine and after intubation,separately in 1,2,3,5 and 10 min. Finally,deal with the data statistically.Results : The HR of Group 2 which took esmolol 2 mg/kg was under Group 1 whic h took esmolol 1 mg/kg evidently;while the HR of Group 1 which took esmolo l 1 mg/kg is under Group 3 which took pumping brine. It made no evident diff erence in each BP group by each time.Conclusions:Esmolo take ef fects on cardiovascular reaction in patients undergoing tracheal intubation,and the effects are related to the medicament and the dosage;Esmolo take effects on the ascending blood pressure which caused by tracheal intubation,but the effec ts are not evident.