猕猴自发性糖尿病动物模型的初步探讨

Discussion of Rhesus Monkey Model of the Spontaneous Diabetes

目的 为进一步克隆糖尿病基因、转基因和基因敲除进行基因治疗 ,以及应用自发性糖尿病猕猴模型开展糖尿病基因功能表达研究。方法 从正常饲养猕猴种群中 ,采用葡萄糖耐量试验和尿糖测试实验方法 ,筛选自发性糖尿病模型。结果和结论 从 10 0只老龄猕猴群中筛选出了

Objective To study the rhesus monkey model of the spontaneous diabetes for cloning the gene of diabetes (gene transfer,gene knock-out and gene therapy) and discussing the gene function and expression. Methods The GTT (glucose tolerance test) and glycosuria test in breeding rhesus monkeys were used to choose the rhesus monkey model of the spontaneous diabetes. Results and Conclusion 3 monkeys which were abnormal in glucose tolerance test and positive in glycosuria test were screened from 100 monkeys in middle and elderly age.