固齿丸合螺旋霉素治疗牙周病的临床研究

Clinical Study of Combined Gu Chi Wan(固齿丸)and Spiramycin in the Treatment of Periodontal Disease

本文旨在观察补肾中药固齿丸结合牙周病基础治疗的疗效。选中～重度各型牙周炎90例,随机分为固齿丸组和螺旋霉素组。通过3、6、12、24个月的随访,表明治后2年两组疗效有明显的差异;固齿九组的GI(龈炎指数)、PDI(牙周指数)下降幅度均大于螺旋霉素组(P<0.001),X线片示出现牙槽骨修复的牙数固齿丸组(236)也明显多于螺旋霉素组(17)。说明固齿九治疗牙周病是有效的。

The purpose of the present study is to evaluate clinical effect of the integrated traditional Chinese and western medicine in the treatment of periodontal disease. 90 patients suffered from mild to advanced periodontitis were divided into two groups. The Gu Chi Wan (tooth firming pills) group was administered tooth firming pills 4 mg twice daily for 3～6 months combined with spiramycin 0.2 four times daily for 5 days and routine periodontal treatment. The spiramycin group, as control, was administered spiramycin 0.2 four times daily for 5 days combined with routine periodontal treatment. The clinical parameters: GI, PLI, PDI and serial radiographs were checked on the beginning of study and through 3, 6,12, 24 months follow up study. The results showed that the GI and PDI of the Gu Chi Wan group decreased significantly than the control group (P<0.001). the inflammatory recurrence rate was 33% in the control group and 12% in Gu Chi Wan group and the serial radiographs demonstrated that a higher incidence of bone fill occurred in Gu Chi Wan group than in the control group (P<0.01)