大剂量华蟾素防治恶性血液病化疗时感染及粒细胞减少

Clinical Observation of High Dose Cinobufocini in Attenuation and Treatment of Infection and Granulocytopenia during Combined Chemotherapy of Malignant Blood Diseases

本文采用自身对照方法观察了30例恶性血液病患者联合化疗时应用大剂量华蟾素(109/日)预防治疗感染及粒细胞减少的临床效果。结果表明,大剂量华蟾素能明显减少恶性血液病化疗时感染的发生率和持续时间,减轻化疗药物对骨髓的抑制,且无明显副作用。

The use of high dose Cinobufocini in attenuation and treatment of infection and granolocytopenia during combined chemotherapy was observed In patients with malignant blood diseases. The study was designed in such a way.that each patient served as self control. The patients,18 males and 12 females, aged 16～66 (average 34).62 experiments in 20 patients with acute leukemia,8 with malignant lymphoma and 2 with multiple myeloma were observed. In patients with the treatment of high dose Cinobufocini, infection was significantly decreased and the number of granulocytes was not markedly changed before and after the treatment. The observation demonstrated that high dose Cinobufocini can significantly reduce the risk of infection and degree and duration of granulocytopenia associated with chemotherapy of patients with malignant blood diseases, The use of high dose Cinobufocini is simple and convenient and with very little side effects.