再生障碍性贫血的辨证分型与外周血T淋巴细胞亚群、红细胞C_3b受体的关系

Relationship of Syndrome Differentiation in TCM of Chronic Aplastic Anemia, Peripheral Blood's T-Lymphocyte Subpopulation and RBC C_3b Receptors

运用间接葡萄球菌A蛋白(SPA)花环法和红细胞C_3b受体花环试验,对51例再生障碍性贫血(下称再障)患者进行了辨证分型及T淋巴细胞正群、红细胞C_3b受体花环率检测。结果T淋巴细胞亚群的改变以肾阴虚型最重,肾阴阳两虚型最轻,肾阳虚型介于二者之间;三型红细胞C_3b受体花环率均低于健康对照组(P<0.01)。表明再障各型T淋巴细胞亚群紊乱的程度不同,红细胞免疫功能低下。这种特征性的改变可作为微观辨证的参考指标,亦可为临床应用免疫制剂提供指导。

In this paper, the Syndrome Differentiation in TCM and the determination on T-lymphocytesubpopulation and RBC C_3b receptor were carried out by using indirect SPA assay and RBC C_3breceptor ring test among 51 chronic aplastic anemia patients. Result. The OKT_3 OKT_4 and OKT_4/OKT_3 ratio in groups of Kidney-Yin Deficiency group were lower. while the OKT_8 was higher thanthat of controls. In the group of both Kidney-Yin and Yang Deficiency, OKT_4 and OKT_4/OKT_8 ratiowere lower. and the value of OKT_8 is higher than that of controls. The OKT_8 in the Kidney-YangDeficiency group was higher. and the ratio of OKCT_4/OKT_8 was lower than that of controls. TheOKT_8 in the Kidney-Yin Deficiency group among three groups increased higher than that of othertwo groups. while the OKT_4/OKT_8 ratio reduced. The OKT_4/OKT_8 ratio in the group of bothKidney-Yin and Yang Deficiency was higher than that of Kidney-Yang Deficiency group. Among the three groups, the rosette rates of RBC C_3 breceptor were lower than controls. The above-mentioneddata were statistically significant. These characteristic changes could be used as a reference ofmicrocosmic Syndrome Differestiation and also a guide for how to apply the immunosupressant andimmunopotentiator.