冬虫夏草对慢性肾功能衰竭T细胞亚群的影响

Effect of Cordyceps Sinesis on T-Lymphocyte Subsets in Chronic Renal Failure

对51例慢性肾功能衰竭(简称肾衰)同步做有关肾功能指标及T细胞亚群检测,其中28例为口服冬虫夏草动态观察组。结果:肾衰组T细胞亚群较正常对照组明显降低(P均<0.01),且白蛋白(ALb)、血红蛋白(Hb)均与OKT_4、OKT_4/OKT_3呈正相关(P均<0.05);动态组经配对t检验,OKT_4、OKT_4/OKT_8明显升高(P均<0.05),肾功能各指标均有明显改善(P<0.05～0.01),显示冬虫夏草可明显改善肾衰患者的肾功能状态和提高细胞免疫功能。

Synchroneous measurements of renal function and T-cell subsets were taken in 51 cases of chronic renal failure (CRF)patients.Cordyceps sinesis 3.5g/d was given to 28 out of these 51 patients, which was considered as follow-up group.The results were stated as follows:(1) Obvious decrease of OKT_3,OKT_4, OKT_4/OKT_8 was found in CRF(P<0.01).(2) OKT_4 and OKT_4/OKT_8were propor-tional to plasma albumin and Hb levels(P<0.05).(3) After administration of Cordyceps sinesis,improvement of renal functiom and OKT_4,OKT_4,/OKT_8 were confirmed. This study indicated that cellular immune function was decreased in CRF.Administration of Cordyceps sinesis might improve their renal function and as the same time enhance the cellular immune function in CRF