强肌健力胶囊对重症肌无力患者口腔粘膜遗传毒性损害的保护作用

Reduction of Genotoxic Damage in Oral Mucosa with Myasthenia Gravis by TCM

应用Stich等所建立的口腔粘膜脱落上皮细胞的微核测试技术,对重症肌无力患者(40例)进行了检测,并以正常人组(54例)作为对照。结果:微核细胞出现率前者为9.56±1.55‰,后者为2.30±0.03±(P<0.001)。其中22例患者经健脾益气中药强肌健力胶囊治疗1～3个月后,微核细胞出现率由14.38士2.33‰下降至6.00士0.82‰(P<0.002)。此外,脾虚组的微核细胞出现率显著高于非脾虚组(P<0.05)。结果提示:重症肌无力患者存在着不同程度的细胞遗传学损伤,脾虚体质与这种损伤有一定关系,健脾益气中药强肌健力胶囊有逆转这种损伤的作用。

Micronucleated exfoliated cell(MEC) of oral mucosa of 40 patients with myasthenia gravis (MG) and 54 normal controls were observed by means of micronucleus test. The frequency of MEC of two groups were 9.56‰ and 2.55‰ respectively, and their difference was remarkably significant (P<0. 001).22 cases were treated by TCM Qiang Ji Jian Li Capsule(强肌健力胶囊).The frequency of MEC after treatment fell from 14.38‰ to 6.00‰.The difference was significant (P<0.002). The frequency of Spleen-asthenia(脾虚) group higher than that of non-Spleen-asthenia (P<0.05). The results revealed that: The patients with MG had genotoxic damage. (2)The constitution with the Spleen-asthenia and the genotoxic damage was related. (3) Qiang Ji Jian Li Capsule of invigorating the Spleen and benefiting Qi(气) could reduce the genotoxic damage.