四种中药预防肝硬变发生的实验研究

An Experimental Study on Preventing the Liver Cirrhosis by Using Four Chinese Herbs

用以CCl_4为主的复合因素制造大白鼠肝硬变动物模型,同时分别用丹参、红花、当归、桃仁四种中药进行治疗,观察肝硬变形成情况。结果显示:丹参组动物肝脏纤维增生明显减轻、胶原蛋白含量减少,全部鼠均未发生肝硬变;红花抑制纤维增生的作用次于丹参;当归和桃仁抑制肝纤维增生的作用在本实验剂量下不显著。

55 rats were divided into six groups;(1) normal control, (2) cirrhosis control,(3)Chinese herbs groups.2-6 groups were liver cirrhosis model caused by combined factor dorminated by CC1_4, and 3-6 groups were given Chinese herbs simultaneously untill the end of sixth week. Radix Salviae miltlorrhizae (RSM)were used in group 3, Flos Carthami (FC) in group 4, Radix Angelicae sinensis (RAS) in group 5, Semen persicae (SP)in group 6. The results: in group 2, 7 out of 9 rats developed into cirrhosis, the degree of fibrosis was 2.55^+ and collagen protein content was 35.3mg/g.liver, SGPT 387u. In group 3(RSM), no cirrhosis was found, the degree of the fibrosis was 0.43^+(compared with group 2, P<0.01,collagen protein content was 16.7mg/g. liver (P<0.01), SGPT 132u(P<0.01).In group 4(FC), 8 out of 9 rats did not develope into cirrhosis,collagen content 21.1mg/g·liver,compared with group 2, P<0.05. In the group of 5 and 6,some rats were developed into cirrhosis. The result showed that RSM and FC possessed an inhibitory effect on fibrogenesis. The effect of RSM was remarkable. It could prevent experimental ccirrhosis. The effect of RAS and SP were uncertain. This experiment predicted that RAM would become the promising drug to restrain chronic hepatic disease from developing into cirrhosis clinically