血虚证患者血浆心钠素与心功能变化的相关分析

Study of the Correlation Analysis between Plasma ANP and Cardiac Function in Blood Deficiency Syndrome

通过检测血虚证患者的血浆心钠素、心输出量等指标,发现血虚组患者血浆心钠素较健康对照组明显升高,心输出量较健康对照组明显减少,外周阻力增加。并对血虚证血浆心钠素与心功能变化的相关性、血浆心钠素作用与中医"心主血"理论的相关性、心与血的内在联系等问题进行了讨论。

The function of ANP in the cardiovascular regulation is very similar with the TCM theory of 'the Heart governs blood circulation'. Using the method of cardiac impedance to check cardiac output and the method of radioimmunoassay (RIA) to check plasma ANP, the result showed that in the status of Blood Deficiency Syndrome, cardiac function was impaired, thete were reduced kinemia and stroke volume, as well as markedly raised plasma ANP and peripheral resistance. The above-mentioned indexes were signficantly different from those of normal group (P<0.01). Using multivariate regression analysis, cardiac output was negatively correlated with the plasma ANP (P<0.05). 23 cases with Blood Deficiency Syndrome showed normal emoglobin, but an evidently changed cardiac output and plasma ANP were closely related with the level of the Blood Deficiency.Both parameters might serve as the objective basis to reflect the level of Blood Deficiency to facilitate the clinical diagnosis of the patient.