潜熄宁治疗阴虚阳亢型高血压病60例临床研究

Clinical Study of Qianxining(潜息宁) on Treatment of 60 Cases with Yang Hyperactivity(阳亢) due to Yin Deficiency(阴虚) Type of Hypertension

60例阴虚阳亢型高血压病患者随机分为中药治疗组和西药对照组进行治疗研究。结果:(1)两组降压总有效率和血压下降幅度无显著差异;(2)治疗组改善症状和改善植物神经功能紊乱效果显著;(3)两组治疗前后HR、SV、血浆PRA、TXB_2与6-Keto-PGF_(1α)等指标,均有改变,治疗组TXB_2/6-Keto-PGF_(1α)比值显著降低;(4)治疗组血脂增高患者TC、TG显著降低。说明潜熄宁对本病具有一定的治疗作用。

60 cases with Yang Hyperactivity due to Yin Deficiency type of hypertension were randomly divided into two groups. One was treated with TCM and the other with WM as control. The results showed that: (1) there were no significant differences in the total effective rate and the amplitude of lowering of blood pressure between two groups; (2) the improvement of symptoms and distur-bance of autonomic nerve was significant in TCM group in comparison with control, (3) there were some changes in HR, SV, plasma PRA, TXB_2 and 6-keto-PGF_1 α level in both groups, but the decrease of TXB_2/6-keto-PGF_1α ratio was significant in TCM group only (P<0.05); (4) TC and TG in patients with hyperlipemia showed a remarkab1e drop in TCM group (P<0.02; P<0.005). All these revealed that Qianxining was a satisfactory hypotensive remedy and a further exploration of its mechanism is suggested.