保元汤对慢性肾衰患者红系祖细胞的作用及临床疗效观察

The Effect of Baoyuantang on Erythroid Progenitor and Clinical Observation in Chronic Renal Failure Patients

用保元汤治疗虚证慢性肾功能衰竭(CRF)患者12例,观察该方对红系集落形成的作用,同时作临床疗效分析。结果显示该方能降低血肌酐,显效4例,有效6例。CRF血清对正常骨髓红系集落形成有抑制作用,治疗后这种抑制作用减弱,患者Hb增高。且Hb与红系集落形成呈正相关,与血肌酐呈负相关。提示保元汤改善CRF贫血与提高红系造血祖细胞增殖、分化能力及降低血肌酐有关。

The erythroid colony formating ability and the therapeutic efficacy were investigated in patients with chronic renal failure (CRF) before and after treatment with Baoyuantang, The resuIts showed that the number of CFU-E, BFU-E of bone marrow was found lower in CRF patieats than that in normal controls, and there was inhibitory action in the CRF serum on the number of CFU-E, BFU-E of normal human bone marrow. After treatment with Baoyuantang, the amount of Hb was increased and creatinine decreased in CRF patients, and its effective rate reached 83.3%. The above-mentioned inhibitory action in CRF serum was also reduced post-treatmentally. The results indicated that Baoyuantang could increase the ability for proliferation and differentiation of erythroid progenitor and adjust anemia in CRF patient.