益气活血解毒汤加激素治疗肾病综合征疗效观察

Therapeutic Changes of Nephrotic Syndrome Treated with Yiqi Huoxue Jiedu Decoction and Corticosteroid

对87例原发性肾病综合征(简称肾综)血浆及尿血栓素B_2(TXB_2)及6-酮-前列环素(6-酮-PGE_(1α))含量及益气活血解毒汤治疗前后的改变进行了观察。结果表明,肾综Ⅰ型及Ⅱ型血浆及尿TXB_2及TXB_2/6-酮-PGF_(1α)比值均显著高于对照组(P<0.01～0.05),治疗后TXB_2及TXB_2/6-酮-PGF_(1α)比值明显降低(P<0.01～0.05),完全缓解62例。提示益气解毒活血汤有抑制TXB_2合成及调整TXB_2 6-酮-PGF_(1α)平衡作用,从而提高疗效。以阴虚型及气阴两虚型疗效较好。

Plasmic and urinary TXB_2 and 6-Keto-PGF_(1α) of 87 patients of nephrotic syndrome (NS) and 25 healthy subjects were measured by RIA, and the influence of Yiqi Huoxue Jiedu decoction (YHJ) and corticosteroid on above-mentioned parameters was investigated. Results: Plasmic and urinary TXB_2 as well as the ratio of TXB_2/6-K-PGF_(1α) of both types of NS increased (P<0.01-0.05). The plasmic TXB_2 of II type was higher than that of I type of NS (P<0.01), 6-K-PGF_(1α) increased as well (P<0.05), After treatment, plasmic and urinary TXB_2 of both types of NS were remarkably lower (P<0.01), while urinary 6-K-PGF_(1α) increased significantly (P<0.05). In comparing with pre-treatmental investigation, the plasmic 6-K-PGF_(1α) of II type was reduced (P<0.05). It was shown that YHJ would inhibit the synthesis of TXA_2 and regulate the TXA_2-PGI_2 balance. YHJ was markedly effortive in producing TXB_2 and 6-K-PGF_(1α) increase, its therapeutical effects was better to patients with Yin Deficiency and both Qi-Yin Deficiency, but not so well with Yang Deficiency Syndrome.